Structural Analysis - Application of imaging protocols for analysis of changes in brain structure and volumes. Changes in grey and white matter volumes along with the volumes of brain nuclei such as the hippocampus will be mapped.

FMRI - Applications will examine cognitive changes in TBI. Changes in memory, response times, fine motor function, and perception will be examined utilizing standardized tasks.

Spectroscopy - Analysis of chemical changes associated with traumatic brain injury and long term sequela. Chemical signatures of standard brain metabolites will be determined and stored in the database.

DTI - Ultrastructural analysis of white matter disruption or dysfunction in TBI patients. Changes in axonal diffusion properties as a probe for areas of dysfunction. Optimization of acquisition parameters and development of secondary image processing capabilities.

Nuclear Medicine Studies with SPECT and PET-CT will focus on:
1. Perfusion abnormalities associated with traumatic injury
2. Metabolic changes in glucose utilization with FDG-PET